Imaging Method by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI-MS) for Tissue or Tumor: A Mini Review

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is an advanced technique that uses minimum fragmented ions from complex molecules for (MS) analysis (tissue profiling by spectrometry). It able to analyze spatially resolved tissue or tumor sections at the molecular level. has become a valuable tool and imaging, due its ease of operation high resolution, but it still vast room development in instrumentation larger proteins some tissues. In this review, we focus on main components MALDI-MS instrumentation, sample handling processing, working principle MALDI-MS, applications diagnostic prognostic assessments, removal drug development. Although less effective detecting tissues, shows huge potential because advancements processing protocols. This article may benefit those who have interests imaging.